| 1. Jornada | 18.07.2016 | Santos Laguna | - | UANL Tigres | 0:0 | ||||
| 2. Jornada | 23.07.2016 | CD Veracruz | - | Santos Laguna | 2:0 | ||||
| 3. Jornada | 01.08.2016 | Santos Laguna | - | Monarcas Morelia | 2:4 |  |
|||
| 4. Jornada | 08.08.2016 | Puebla FC | - | Santos Laguna | 0:0 | ||||
| 5. Jornada | 15.08.2016 | Santos Laguna | - | Deportivo Guadalajara | 0:1 | ||||
| 6. Jornada | 21.08.2016 | Cruz Azul | - | Santos Laguna | 3:1 |  |
|||
| 7. Jornada | 29.08.2016 | Santos Laguna | - | Club León | 1:0 | ||||
| 8. Jornada | 11.09.2016 | Club Necaxa | - | Santos Laguna | 2:1 | ||||
| 9. Jornada | 19.09.2016 | Santos Laguna | - | Pumas UNAM | 3:1 | ||||
| 10. Jornada | 22.09.2016 | CF Monterrey | - | Santos Laguna | 5:2 | |
|
||
| 11. Jornada | 26.09.2016 | Santos Laguna | - | Club Tijuana | 1:2 | |
|
||
| 12. Jornada | 02.10.2016 | Gallos Blancos | - | Santos Laguna | 1:1 | ||||
| 13. Jornada | 16.10.2016 | CF Pachuca | - | Santos Laguna | 3:0 | ||||
| 14. Jornada | 24.10.2016 | Santos Laguna | - | Atlas Guadalajara | 2:2 | |
|
||
| 15. Jornada | 30.10.2016 | CF América | - | Santos Laguna | 3:1 | ||||
| 16. Jornada | 07.11.2016 | Santos Laguna | - | Chiapas FC | 2:0 | ||||
| 17. Jornada | 20.11.2016 | Deportivo Toluca | - | Santos Laguna | 1:2 | |
Argentina
Italia 
