| 3. Jornada | 15.02.2021 | Sol de América | - | River Plate | 1:1 |  |
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| 4. Jornada | 19.02.2021 | River Plate | - | Sportivo Luqueño | 1:0 | ||||
| 5. Jornada | 02.03.2021 | Libertad | - | River Plate | 2:1 | |
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| 6. Jornada | 05.03.2021 | River Plate | - | Guaireña FC | 0:1 | ||||
| 8. Jornada | 13.03.2021 | River Plate | - | Club Nacional | 0:0 |  |
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| 11. Jornada | 13.04.2021 | Guaraní | - | River Plate | 2:0 | ||||
| 12. Jornada | 18.04.2021 | River Plate | - | Sol de América | 0:2 | |
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| 13. Jornada | 27.04.2021 | Sportivo Luqueño | - | River Plate | 2:2 | ||||
| 17. Jornada | 24.05.2021 | Club Nacional | - | River Plate | 0:1 | |
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| 18. Jornada | 30.05.2021 | River Plate | - | Club Olimpia | 1:2 |
Paraguay