| 8. Jornada | 12.09.2021 | Sportivo Luqueño | - | River Plate | 0:2 | ||||
| 9. Jornada | 18.09.2021 | River Plate | - | Libertad | 0:1 | ||||
| 10. Jornada | 27.09.2021 | River Plate | - | Club Olimpia | 1:2 | ||||
| 11. Jornada | 03.10.2021 | River Plate | - | Guaireña FC | 1:1 | ||||
| 16. Jornada | 20.11.2021 | Guaraní | - | River Plate | 2:1 |  |
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| 17. Jornada | 26.11.2021 | River Plate | - | Sportivo Luqueño | 0:0 | ||||
| 18. Jornada | 03.12.2021 | Libertad | - | River Plate | 5:0 |
Paraguay