| 2. Jornada | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 5. Jornada | 05.02.2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 7. Jornada | 19.02.2022 | Club Tijuana [] | - | CF Monterrey [] | 1:1 | ||||
| 11. Jornada | 19.03.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 | ||||
| 14. Jornada | 05.04.2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:3 | ||||
| 16. Jornada | 23.04.2022 | Club León [] | - | Club Tijuana [] | 2:1 |  |
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| 17. Jornada | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 | ||||
| 18. Jornada | 07.05.2022 | CF Monterrey [] | - | Club Tijuana [] | 1:0 |
México