| 1. Jornada | 22.01.2020 | Blooming | - | Real Santa Cruz | 1:1 |  |
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| 2. Jornada | 27.01.2020 | Real Santa Cruz | - | The Strongest | 3:2 | |
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| 4. Jornada | 02.02.2020 | Real Potosí | - | Real Santa Cruz | 2:1 | ||||
| 3. Jornada | 05.02.2020 | Real Santa Cruz | - | Club San José | 1:1 | ||||
| 5. Jornada | 09.02.2020 | Always Ready | - | Real Santa Cruz | 6:0 | ||||
| 7. Jornada | 16.02.2020 | Real Santa Cruz | - | Oriente Petrolero | 1:5 | ||||
| 8. Jornada | 22.02.2020 | Atlético Palmaflor | - | Real Santa Cruz | 2:1 | ||||
| 9. Jornada | 27.02.2020 | Real Santa Cruz | - | Bolívar | 2:4 | ||||
| 13. Jornada | 27.11.2020 | Real Santa Cruz | - | Club Aurora | 4:2 | ||||
| 14. Jornada | 30.11.2020 | Real Santa Cruz | - | Blooming | 0:2 | ||||
| 15. Jornada | 03.12.2020 | The Strongest | - | Real Santa Cruz | 4:2 | |
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| 22. Jornada | 22.12.2020 | Bolívar | - | Real Santa Cruz | 4:0 | |
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| 23. Jornada | 24.12.2020 | Real Santa Cruz | - | Royal Pari | 2:4 | ||||
| 24. Jornada | 27.12.2020 | Nacional Potosí | - | Real Santa Cruz | 1:0 | |
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| 25. Jornada | 29.12.2020 | Real Santa Cruz | - | CD Guabirá | 4:4 | |
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Panamá