| 2. Jornada | 30.07.2022 | Independiente de La Chorrera | - | San Francisco FC | 2:0 | ||||
| 3. Jornada | 06.08.2022 | San Francisco FC | - | Atlético Chiriquí | 0:0 | ||||
| 4. Jornada | 09.08.2022 | Veraguas United | - | San Francisco FC | 3:1 | ||||
| 5. Jornada | 13.08.2022 | San Francisco FC | - | Herrera FC | 5:0 |  |
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| 6. Jornada | 20.08.2022 | Árabe Unido | - | San Francisco FC | 2:0 | ||||
| 7. Jornada | 29.08.2022 | San Francisco FC | - | Alianza | 0:1 | ||||
| 8. Jornada | 03.09.2022 | San Francisco FC | - | Tauro FC | 1:2 |  |
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| 9. Jornada | 12.09.2022 | Sporting San Miguelito | - | San Francisco FC | 2:1 | ||||
| 10. Jornada | 17.09.2022 | Plaza Amador | - | San Francisco FC | 1:2 | |
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| 11. Jornada | 24.09.2022 | San Francisco FC | - | Potros del Este | 2:0 | ||||
| 12. Jornada | 28.09.2022 | San Francisco FC | - | UD Universitario | 1:1 | ||||
| 13. Jornada | 01.10.2022 | San Francisco FC | - | Independiente de La Chorrera | 0:2 | |
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| 15. Jornada | 15.10.2022 | San Francisco FC | - | Veraguas United | 1:1 | ||||
| 16. Jornada | 23.10.2022 | Herrera FC | - | San Francisco FC | 0:2 |
Panamá