| 1. Jornada | 11.01.2021 | Santos Laguna | - | Cruz Azul | 1:0 | ||||
| 3. Jornada | 23.01.2021 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
| 4. Jornada | 01.02.2021 | Santos Laguna | - | CF América | 1:1 |  |
|||
| 5. Jornada | 07.02.2021 | Atlas Guadalajara | - | Santos Laguna | 1:1 | ||||
| 6. Jornada | 15.02.2021 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 7. Jornada | 19.02.2021 | Atlético San Luis | - | Santos Laguna | 1:0 | ||||
| 10. Jornada | 08.03.2021 | Santos Laguna | - | Club Necaxa | 3:1 | ||||
| 11. Jornada | 14.03.2021 | Club Tijuana | - | Santos Laguna | 0:1 | ||||
| 13. Jornada | 05.04.2021 | Deportivo Guadalajara | - | Santos Laguna | 1:1 | ||||
| 14. Jornada | 12.04.2021 | Gallos Blancos | - | Santos Laguna | 1:0 | ||||
| 16. Jornada | 27.04.2021 | CF Pachuca | - | Santos Laguna | 1:0 | ||||
| 17. Jornada | 03.05.2021 | Santos Laguna | - | Puebla FC | 0:0 |
México