| 1. Jornada | 20.05.2021 | Unión Huaral | - | Santos FC | 1:3 | ||||
| 2. Jornada | 26.05.2021 | Santos FC | - | Chavelines Juniors | 2:1 |  |
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| 3. Jornada | 30.05.2021 | Deportivo Coopsol | - | Santos FC | 1:0 | ||||
| 5. Jornada | 26.06.2021 | Pirata | - | Santos FC | 2:2 | ||||
| 6. Jornada | 03.07.2021 | Santos FC | - | Comerciantes Unidos | 4:2 | |
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| 7. Jornada | 08.07.2021 | Atlético Grau | - | Santos FC | 4:1 | |
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| 8. Jornada | 12.07.2021 | Unión Comercio | - | Santos FC | 0:2 | |
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| 9. Jornada | 16.07.2021 | Santos FC | - | Llacuabamba | 0:1 | ||||
| 10. Jornada | 22.07.2021 | Cultural Santa Rosa | - | Santos FC | 3:0 | ||||
| 11. Jornada | 29.07.2021 | Santos FC | - | Carlos Stein | 1:1 |
Colombia
