| 1. Jornada | 26.02.2022 | FC Dallas | - | Toronto FC | 1:1 | ||||
| 2. Jornada | 05.03.2022 | Toronto FC | - | New York RB | 1:4 |  |
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| 2. Jornada | 19.03.2022 | Toronto FC | - | D.C. United | 2:1 | ||||
| 3. Jornada | 02.04.2022 | Toronto FC | - | New York City FC | 2:1 | ||||
| 3. Jornada | 10.04.2022 | Real Salt Lake | - | Toronto FC | 2:2 |  |
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| 3. Jornada | 24.04.2022 | New York City FC | - | Toronto FC | 5:4 | ||||
| 3. Jornada | 30.04.2022 | Toronto FC | - | FC Cincinnati | 1:2 | ||||
| 4. Jornada | 14.05.2022 | Toronto FC | - | Orlando City | 0:1 | ||||
| 4. Jornada | 22.05.2022 | D.C. United | - | Toronto FC | 2:2 | |
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| 4. Jornada | 29.05.2022 | Toronto FC | - | Chicago Fire | 3:2 | ||||
| 5. Jornada | 19.06.2022 | New York RB | - | Toronto FC | 2:0 | |
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| 5. Jornada | 26.06.2022 | Toronto FC | - | Atlanta United FC | 2:1 | |
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| 6. Jornada | 03.07.2022 | Toronto FC | - | Seattle Sounders | 0:2 | |
México
