| 11. Jornada | 25.09.2021 | Santa Fe | - | Envigado FC | 3:1 | ||||
| 12. Jornada | 02.10.2021 | Deportes Tolima | - | Santa Fe | 0:0 | ||||
| 13. Jornada | 12.10.2021 | Patriotas FC | - | Santa Fe | 0:1 |  |
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| 14. Jornada | 18.10.2021 | Santa Fe | - | Millonarios | 0:2 | ||||
| 15. Jornada | 25.10.2021 | Atlético Huila | - | Santa Fe | 1:2 | ||||
| 16. Jornada | 28.10.2021 | Santa Fe | - | Jaguares de Córdoba | 3:1 |  |
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| 17. Jornada | 02.11.2021 | Deportes Quindío | - | Santa Fe | 1:1 | |
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| 18. Jornada | 07.11.2021 | Santa Fe | - | Atlético Junior | 1:1 | ||||
| 19. Jornada | 16.11.2021 | Once Caldas | - | Santa Fe | 2:1 |
Colombia
Francia 
