| 3. Jornada | 20.06.2021 | Columbus Crew | - | Chicago Fire | 2:0 | ||||
| 3. Jornada | 24.06.2021 | Chicago Fire | - | FC Cincinnati | 0:1 | ||||
| 5. Jornada | 05.08.2021 | Chicago Fire | - | New York City FC | 0:0 | ||||
| 5. Jornada | 09.08.2021 | Chicago Fire | - | New York RB | 2:1 | ||||
| 5. Jornada | 16.08.2021 | Chicago Fire | - | Columbus Crew | 1:0 | ||||
| 5. Jornada | 19.08.2021 | Inter Miami CF | - | Chicago Fire | 3:2 | ||||
| 5. Jornada | 22.08.2021 | Orlando City | - | Chicago Fire | 1:0 |  |
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| 5. Jornada | 29.08.2021 | New York RB | - | Chicago Fire | 0:1 | |
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| 6. Jornada | 12.09.2021 | Sporting Kansas City | - | Chicago Fire | 2:0 | ||||
| 6. Jornada | 16.09.2021 | D.C. United | - | Chicago Fire | 3:0 | |
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| 6. Jornada | 19.09.2021 | CF Montréal | - | Chicago Fire | 2:0 | |
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| 6. Jornada | 23.09.2021 | Chicago Fire | - | New England Revolution | 2:3 |  |
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| 8. Jornada | 07.11.2021 | Columbus Crew | - | Chicago Fire | 2:0 |
Colombia