| 1. Jornada | 12.08.2018 | Southampton | - | Burnley FC | 0:0 | ||||
| 2. Jornada | 18.08.2018 | Everton | - | Southampton | 2:1 |  |
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| 3. Jornada | 25.08.2018 | Southampton | - | Leicester City | 1:2 | ||||
| 4. Jornada | 01.09.2018 | Crystal Palace | - | Southampton | 0:2 | ||||
| 5. Jornada | 17.09.2018 | Southampton | - | Brighton & Hove Albion | 2:2 | |
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| 6. Jornada | 22.09.2018 | Liverpool | - | Southampton | 3:0 | ||||
| 7. Jornada | 29.09.2018 | Wolverhampton Wanderers | - | Southampton | 2:0 | ||||
| 8. Jornada | 07.10.2018 | Southampton | - | Chelsea | 0:3 | |
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| 9. Jornada | 20.10.2018 | Bournemouth | - | Southampton | 0:0 | ||||
| 10. Jornada | 27.10.2018 | Southampton | - | Newcastle United | 0:0 | ||||
| 11. Jornada | 04.11.2018 | Manchester City | - | Southampton | 6:1 | ||||
| 12. Jornada | 10.11.2018 | Southampton | - | Watford FC | 1:1 | |
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| 13. Jornada | 24.11.2018 | Fulham FC | - | Southampton | 3:2 | ||||
| 14. Jornada | 01.12.2018 | Southampton | - | Manchester United | 2:2 |  |
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| 15. Jornada | 05.12.2018 | Tottenham Hotspur | - | Southampton | 3:1 | ||||
| 21. Jornada | 02.01.2019 | Chelsea | - | Southampton | 0:0 | ||||
| 22. Jornada | 12.01.2019 | Leicester City | - | Southampton | 1:2 | ||||
| 23. Jornada | 19.01.2019 | Southampton | - | Everton | 2:1 |
Alemania
