| Tercera ronda | 21.04.2022 | Orlando City | - | Tampa Bay Rowdies | 2:1 | ||||
| Cuarta Ronda | 11.05.2022 | Orlando City | - | Philadelphia Union | 2:1 | ||||
| Octavos de final | 26.05.2022 | Orlando City | - | Inter Miami CF | 4:2 pn. |  |
|||
| Cuartos de final | 30.06.2022 | Orlando City | - | Nashville SC | 6:5 pn. | ||||
| Semifinales | 28.07.2022 | Orlando City | - | New York RB | 5:1 |  |
|
||
| Final | 08.09.2022 | Orlando City | - | Sacramento Republic | 3:0 |
Uruguay