| 1. Jornada | 17.02.2021 | Lobos UPNFM | - | Motagua | 1:2 | ||||
| 3. Jornada | 25.02.2021 | Olimpia | - | Lobos UPNFM | 5:1 | ||||
| 4. Jornada | 28.02.2021 | Lobos UPNFM | - | Real de Minas | 2:0 | ||||
| 5. Jornada | 04.03.2021 | Honduras Progreso | - | Lobos UPNFM | 0:3 | ||||
| 6. Jornada | 07.03.2021 | Motagua | - | Lobos UPNFM | 3:1 |  |
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| 8. Jornada | 18.03.2021 | Lobos UPNFM | - | Olimpia | 2:1 |  |
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| 9. Jornada | 21.03.2021 | Real de Minas | - | Lobos UPNFM | 0:3 | ||||
| 2. Jornada | 24.03.2021 | Real Sociedad | - | Lobos UPNFM | 1:1 | ||||
| 7. Jornada | 29.03.2021 | Lobos UPNFM | - | Real Sociedad | 1:2 | |
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| 10. Jornada | 01.04.2021 | Lobos UPNFM | - | Honduras Progreso | 0:2 | |
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| 11. Jornada | 09.04.2021 | Marathón | - | Lobos UPNFM | 1:1 | ||||
| 12. Jornada | 18.04.2021 | Lobos UPNFM | - | Platense | 0:0 | ||||
| 13. Jornada | 22.04.2021 | Real España | - | Lobos UPNFM | 1:1 | ||||
| 14. Jornada | 28.04.2021 | Lobos UPNFM | - | Vida | 3:1 |
Honduras