| 3. Jornada | 20.02.2022 | Sol de América | - | Guaireña FC | 1:0 | ||||
| 6. Jornada | 14.03.2022 | Guaireña FC | - | 12 de Octubre de Itauguá | 0:0 | ||||
| 8. Jornada | 03.04.2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 9. Jornada | 11.04.2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
| 10. Jornada | 17.04.2022 | Guaireña FC | - | Sportivo Ameliano | 2:1 | ||||
| 11. Jornada | 21.04.2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
| 12. Jornada | 25.04.2022 | Guaraní | - | Guaireña FC | 2:1 | ||||
| 13. Jornada | 02.05.2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
| 14. Jornada | 08.05.2022 | Guaireña FC | - | Sol de América | 2:1 | ||||
| 16. Jornada | 14.05.2022 | Guaireña FC | - | Resistencia SC | 0:0 | ||||
| 20. Jornada | 24.06.2022 | Guaireña FC | - | Tacuary | 0:0 | ||||
| 21. Jornada | 27.06.2022 | Sportivo Ameliano | - | Guaireña FC | 2:2 |  |
 |
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| 22. Jornada | 01.07.2022 | Guaireña FC | - | Club Nacional | 1:1 | |
Paraguay