| 1. Jornada | 12.01.2025 | Deportivo Guadalajara | - | Santos Laguna | 1:0 |  |
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| 3. Jornada | 26.01.2025 | Santos Laguna | - | CF América | 1:4 |  |
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| 4. Jornada | 30.01.2025 | FC Juárez | - | Santos Laguna | 1:0 | ||||
| 5. Jornada | 03.02.2025 | Santos Laguna | - | Puebla FC | 0:2 | ||||
| 6. Jornada | 08.02.2025 | Club Necaxa | - | Santos Laguna | 3:2 |  |
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| 13. Jornada | 31.03.2025 | Santos Laguna | - | Atlético San Luis | 2:3 | ||||
| 14. Jornada | 07.04.2025 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 16. Jornada | 17.04.2025 | Pumas UNAM | - | Santos Laguna | 2:0 | ||||
| 17. Jornada | 21.04.2025 | Santos Laguna | - | Club Tijuana | 0:4 | |
Honduras
España 
