| 1. Jornada | 09.07.2016 | Club Nacional | - | Deportivo Capiatá | 2:2 |  |
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| 2. Jornada | 16.07.2016 | Cerro Porteño | - | Club Nacional | 1:1 | ||||
| 6. Jornada | 07.08.2016 | Club Nacional | - | General Díaz | 1:2 | ||||
| 7. Jornada | 15.08.2016 | Guaraní | - | Club Nacional | 1:0 | ||||
| 8. Jornada | 20.08.2016 | Club Nacional | - | Club Olimpia | 3:4 |  |
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| 9. Jornada | 27.08.2016 | Club Rubio Ñu | - | Club Nacional | 0:0 | ||||
| 10. Jornada | 10.09.2016 | Club Nacional | - | General Caballero ZC | 4:1 | ||||
| 11. Jornada | 18.09.2016 | River Plate | - | Club Nacional | 2:3 | |
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| 12. Jornada | 25.09.2016 | Deportivo Capiatá | - | Club Nacional | 0:1 | ||||
| 13. Jornada | 03.10.2016 | Club Nacional | - | Cerro Porteño | 1:6 | ||||
| 16. Jornada | 30.10.2016 | Club Nacional | - | Libertad | 1:2 | ||||
| 18. Jornada | 21.11.2016 | Club Nacional | - | Guaraní | 1:1 | ||||
| 20. Jornada | 04.12.2016 | Club Nacional | - | Club Rubio Ñu | 3:1 | ||||
| 21. Jornada | 11.12.2016 | General Caballero ZC | - | Club Nacional | 1:2 | ||||
| 22. Jornada | 18.12.2016 | Club Nacional | - | River Plate | 2:0 |
Paraguay