| 1. Jornada | 08.01.2022 | Club Tijuana [Sub 16] | - | Club León [Sub 16] | 2:2 | ||||
| 2. Jornada | 15.01.2022 | Club León [Sub 16] | - | UANL Tigres [Sub 16] | 0:1 | ||||
| 8. Jornada | 26.02.2022 | Atlas Guadalajara [Sub 16] | - | Club León [Sub 16] | 5:0 | ||||
| 13. Jornada | 02.04.2022 | Mazatlán FC [Sub 16] | - | Club León [Sub 16] | 2:3 | ||||
| 15. Jornada | 16.04.2022 | Atlético San Luis [Sub 16] | - | Club León [Sub 16] | 1:3 | ||||
| 16. Jornada | 23.04.2022 | Club León [Sub 16] | - | Club Tijuana [Sub 16] | 1:0 | ||||
| 17. Jornada | 30.04.2022 | Club León [Sub 16] | - | CF Monterrey [Sub 16] | 1:2 |
México