| 1. Jornada | 25.04.2021 | New England Revolution | - | D.C. United | 1:0 | ||||
| 4. Jornada | 17.07.2021 | Atlanta United FC | - | New England Revolution | 0:1 | ||||
| 4. Jornada | 22.07.2021 | Inter Miami CF | - | New England Revolution | 0:5 | ||||
| 4. Jornada | 26.07.2021 | New England Revolution | - | CF Montréal | 2:1 |  |
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| 5. Jornada | 19.08.2021 | New England Revolution | - | D.C. United | 3:2 | ||||
| 5. Jornada | 22.08.2021 | New England Revolution | - | FC Cincinnati | 4:1 | ||||
| 5. Jornada | 29.08.2021 | New York City FC | - | New England Revolution | 2:0 | ||||
| 6. Jornada | 23.09.2021 | Chicago Fire | - | New England Revolution | 2:3 | ||||
| 7. Jornada | 25.10.2021 | Orlando City | - | New England Revolution | 2:2 |
Colombia