| 2. Jornada | 30.01.2022 | Atlético Huila | - | Barranquilla FC | 0:0 | ||||
| 3. Jornada | 06.02.2022 | Barranquilla FC | - | Real Cartagena | 0:2 | ||||
| 4. Jornada | 13.02.2022 | Real Santander | - | Barranquilla FC | 2:3 | ||||
| 5. Jornada | 19.02.2022 | Barranquilla FC | - | Atlético FC | 1:0 | ||||
| 7. Jornada | 06.03.2022 | Barranquilla FC | - | Bogotá FC | 2:4 | ||||
| 8. Jornada | 10.03.2022 | Orsomarso SC | - | Barranquilla FC | 2:1 |  |
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| 10. Jornada | 26.03.2022 | Deportes Quindío | - | Barranquilla FC | 2:1 | ||||
| 12. Jornada | 11.04.2022 | Boca Juniors de Cali | - | Barranquilla FC | 0:0 | ||||
| 13. Jornada | 16.04.2022 | Barranquilla FC | - | Valledupar FC | 1:1 | ||||
| 14. Jornada | 25.04.2022 | Tigres FC | - | Barranquilla FC | 2:0 | ||||
| 15. Jornada | 04.05.2022 | Barranquilla FC | - | Fortaleza FC | 0:1 |
Colombia