| 21. Jornada | 23.01.2021 | Sint-Truidense VV | - | Royal Excel Mouscron | 0:2 | ||||
| 22. Jornada | 26.01.2021 | Royal Excel Mouscron | - | RSC Anderlecht | 1:1 | ||||
| 23. Jornada | 30.01.2021 | KAS Eupen | - | Royal Excel Mouscron | 1:1 |  |
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| 24. Jornada | 05.02.2021 | Royal Excel Mouscron | - | KV Kortrijk | 0:3 | ||||
| 26. Jornada | 15.02.2021 | Gante | - | Royal Excel Mouscron | 4:0 | ||||
| 27. Jornada | 20.02.2021 | Royal Excel Mouscron | - | Cercle Brugge | 1:2 |  |
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| 28. Jornada | 28.02.2021 | K Beerschot VA | - | Royal Excel Mouscron | 2:2 | ||||
| 29. Jornada | 07.03.2021 | Royal Excel Mouscron | - | Standard Liège | 1:0 | ||||
| 31. Jornada | 20.03.2021 | Royal Excel Mouscron | - | KV Oostende | 0:1 | ||||
| 32. Jornada | 04.04.2021 | Sporting Charleroi | - | Royal Excel Mouscron | 1:1 | |
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| 34. Jornada | 18.04.2021 | Club Brugge KV | - | Royal Excel Mouscron | 4:2 |
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