| 1. Jornada | 27.08.2022 | Colima FC | - | Saltillo FC | 1:1 |  |
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| 3. Jornada | 08.09.2022 | Tulancingo | - | Saltillo FC | 0:2 | ||||
| 4. Jornada | 11.09.2022 | Saltillo FC | - | Lobos ULMX | 3:1 | ||||
| 5. Jornada | 18.09.2022 | Saltillo FC | - | Catedráticos Elite | 3:0 | ||||
| 2. Jornada | 21.09.2022 | Aguacateros CDU | - | Saltillo FC | 4:1 | |
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| 6. Jornada | 25.09.2022 | Reboceros de La Piedad | - | Saltillo FC | 1:0 | ||||
| 8. Jornada | 02.10.2022 | Tampico Madero | - | Saltillo FC | 3:0 | ||||
| 9. Jornada | 08.10.2022 | Saltillo FC | - | Inter de Querétaro | 3:1 | |
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| 10. Jornada | 15.10.2022 | Correcaminos UAT II | - | Saltillo FC | 0:2 | |
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| 11. Jornada | 22.10.2022 | Saltillo FC | - | Gavilanes de Matamoros | 1:1 | |
México