| 1. Jornada | 07.08.2022 | NEC Nijmegen | - | FC Twente | 0:1 | ||||
| 2. Jornada | 14.08.2022 | FC Twente | - | Fortuna Sittard | 3:0 | ||||
| 4. Jornada | 28.08.2022 | FC Volendam | - | FC Twente | 1:0 | ||||
| 3. Jornada | 31.08.2022 | FC Twente | - | SBV Excelsior | 4:0 |  |
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| 5. Jornada | 03.09.2022 | FC Twente | - | PSV | 2:1 | ||||
| 6. Jornada | 11.09.2022 | AZ Alkmaar | - | FC Twente | 1:1 | ||||
| 8. Jornada | 01.10.2022 | FC Twente | - | Vitesse | 3:0 | ||||
| 9. Jornada | 09.10.2022 | Feyenoord | - | FC Twente | 2:0 | ||||
| 16. Jornada | 14.01.2023 | AFC Ajax | - | FC Twente | 0:0 |  |
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| 18. Jornada | 25.01.2023 | Vitesse | - | FC Twente | 2:2 |
Grecia