| 1. Jornada | 21.08.2021 | Paphos FC | - | APOEL Nikosia | 4:0 | ||||
| 3. Jornada | 19.09.2021 | Apollon Limassol | - | APOEL Nikosia | 2:1 | ||||
| 9. Jornada | 06.11.2021 | APOEL Nikosia | - | AEL Limassol | 3:0 | ||||
| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | ||||
| 17. Jornada | 15.01.2022 | Ethnikos Achna | - | APOEL Nikosia | 0:3 | ||||
| 15. Jornada | 09.02.2022 | PAEEK | - | APOEL Nikosia | 1:3 | ||||
| 22. Jornada | 25.02.2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 |  |
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Estados Unidos