| 3. Jornada | 19.02.2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
| 5. Jornada | 04.03.2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
| 6. Jornada | 15.03.2022 | Club Nacional | - | Libertad | 0:3 |  |
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| 7. Jornada | 21.03.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 8. Jornada | 04.04.2022 | Club Nacional | - | Sportivo Ameliano | 2:1 | ||||
| 11. Jornada | 21.04.2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
| 12. Jornada | 26.04.2022 | Club Nacional | - | Sol de América | 0:3 | ||||
| 13. Jornada | 01.05.2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
| 14. Jornada | 07.05.2022 | Club Nacional | - | Resistencia SC | 1:2 | ||||
| 15. Jornada | 10.05.2022 | 12 de Octubre de Itauguá | - | Club Nacional | 1:2 | ||||
| 16. Jornada | 14.05.2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
| 17. Jornada | 23.05.2022 | Libertad | - | Club Nacional | 1:0 | |
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| 19. Jornada | 19.06.2022 | Sportivo Ameliano | - | Club Nacional | 2:2 | ||||
| 20. Jornada | 23.06.2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 21. Jornada | 27.06.2022 | Club Nacional | - | Guaraní | 0:1 | ||||
| 22. Jornada | 01.07.2022 | Guaireña FC | - | Club Nacional | 1:1 |  |
Paraguay