| 3. Jornada | 20.05.2012 | San Jose Earthquakes | - | Columbus Crew | 1:1 | ||||
| 3. Jornada | 24.05.2012 | Seattle Sounders | - | Columbus Crew | 0:2 | ||||
| 5. Jornada | 15.07.2012 | Columbus Crew | - | Sporting Kansas City | 0:2 | ||||
| 5. Jornada | 22.07.2012 | Columbus Crew | - | D.C. United | 1:0 | ||||
| 5. Jornada | 29.07.2012 | Sporting Kansas City | - | Columbus Crew | 1:2 |  |
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| 6. Jornada | 16.08.2012 | Columbus Crew | - | Los Angeles Galaxy | 1:1 | ||||
| 6. Jornada | 20.08.2012 | Houston Dynamo | - | Columbus Crew | 2:2 |  |
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| 6. Jornada | 23.08.2012 | Columbus Crew | - | Toronto FC | 2:1 | ||||
| 6. Jornada | 30.08.2012 | Philadelphia Union | - | Columbus Crew | 1:2 | ||||
| 7. Jornada | 02.09.2012 | Columbus Crew | - | Impact de Montréal | 2:1 |
Estados Unidos