| 16. Jornada | 11.01.2022 | Forest Green Rovers | - | Colchester United | 2:0 | ||||
| 27. Jornada | 15.01.2022 | Colchester United | - | Barrow AFC | 0:2 | ||||
| 28. Jornada | 22.01.2022 | Salford City | - | Colchester United | 0:3 |  |
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| 26. Jornada | 01.02.2022 | Colchester United | - | Rochdale AFC | 1:1 | ||||
| 30. Jornada | 05.02.2022 | Leyton Orient | - | Colchester United | 0:1 | ||||
| 31. Jornada | 08.02.2022 | Mansfield Town | - | Colchester United | 2:1 | ||||
| 33. Jornada | 19.02.2022 | Northampton Town | - | Colchester United | 3:0 | ||||
| 22. Jornada | 22.02.2022 | Colchester United | - | Hartlepool United | 1:2 | ||||
| 37. Jornada | 15.03.2022 | Bristol Rovers | - | Colchester United | 1:0 | ||||
| 38. Jornada | 21.03.2022 | Colchester United | - | Forest Green Rovers | 0:1 | ||||
| 41. Jornada | 09.04.2022 | Colchester United | - | Stevenage FC | 0:2 |
Inglaterra