| 6. Jornada | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
| 7. Jornada | 20.10.2021 | Rentistas | - | Villa Española | 3:1 |  |
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| 8. Jornada | 24.10.2021 | Villa Española | - | Peñarol | 1:3 | |
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| 10. Jornada | 02.11.2021 | Deportivo Maldonado | - | Villa Española | 0:1 |  |
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| 12. Jornada | 13.11.2021 | Cerrito | - | Villa Española | 1:0 | |
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| 13. Jornada | 19.11.2021 | Villa Española | - | Liverpool | 0:3 | ||||
| 14. Jornada | 30.11.2021 | River Plate | - | Villa Española | 4:2 | |
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| 15. Jornada | 05.12.2021 | Villa Española | - | Cerro Largo | 1:1 |  |
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Uruguay