| 7. Jornada | 09.05.2021 | Jorge Wilstermann | - | Always Ready | 5:2 |  |
|||
| 8. Jornada | 10.07.2021 | Royal Pari | - | Jorge Wilstermann | 3:2 | ||||
| 9. Jornada | 16.07.2021 | Jorge Wilstermann | - | Real Potosí | 3:1 | ||||
| 10. Jornada | 22.07.2021 | CD Guabirá | - | Jorge Wilstermann | 3:2 |  |
|||
| 12. Jornada | 01.08.2021 | Bolívar | - | Jorge Wilstermann | 4:0 | ||||
| 13. Jornada | 06.08.2021 | Jorge Wilstermann | - | Club Aurora | 2:1 | ||||
| 14. Jornada | 08.08.2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | ||||
| 15. Jornada | 15.08.2021 | Jorge Wilstermann | - | Club San José | 4:0 | ||||
| 16. Jornada | 20.08.2021 | Jorge Wilstermann | - | Real Santa Cruz | 5:1 | ||||
| 17. Jornada | 22.08.2021 | Nacional Potosí | - | Jorge Wilstermann | 0:1 | ||||
| 18. Jornada | 12.09.2021 | Jorge Wilstermann | - | Oriente Petrolero | 0:1 | ||||
| 24. Jornada | 27.10.2021 | Real Potosí | - | Jorge Wilstermann | 2:2 | ||||
| 25. Jornada | 30.10.2021 | Jorge Wilstermann | - | CD Guabirá | 2:1 | ||||
| 27. Jornada | 28.11.2021 | Jorge Wilstermann | - | Bolívar | 1:0 | ||||
| 28. Jornada | 02.12.2021 | Club Aurora | - | Jorge Wilstermann | 1:1 |
Bolivia