| 1. Jornada | 21.01.2022 | Marathón | - | Platense | 1:0 | ||||
| 3. Jornada | 06.02.2022 | Vida | - | Marathón | 3:0 |  |
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| 5. Jornada | 13.02.2022 | Honduras Progreso | - | Marathón | 2:1 | ||||
| 6. Jornada | 19.02.2022 | Marathón | - | Victoria | 2:3 | ||||
| 7. Jornada | 27.02.2022 | Real Sociedad | - | Marathón | 1:0 | ||||
| 10. Jornada | 13.03.2022 | Marathón | - | Vida | 1:1 | ||||
| 15. Jornada | 13.04.2022 | Marathón | - | Motagua | 0:3 | ||||
| 16. Jornada | 21.04.2022 | Platense | - | Marathón | 1:0 | ||||
| 12. Jornada | 28.04.2022 | Real España | - | Marathón | 3:1 |
Honduras