| 1. Jornada | 31.07.2022 | Olancho FC | - | Victoria | 1:1 |  |
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| 2. Jornada | 07.08.2022 | Vida | - | Olancho FC | 1:0 | ||||
| 5. Jornada | 21.08.2022 | Real Sociedad | - | Olancho FC | 1:2 | ||||
| 6. Jornada | 28.08.2022 | Olancho FC | - | Motagua | 0:1 | ||||
| 7. Jornada | 01.09.2022 | Lobos UPNFM | - | Olancho FC | 1:2 | ||||
| 8. Jornada | 04.09.2022 | Olancho FC | - | Real España | 3:1 | ||||
| 9. Jornada | 11.09.2022 | Olancho FC | - | Marathón | 2:3 | ||||
| 11. Jornada | 02.10.2022 | Olancho FC | - | Vida | 2:1 | ||||
| 12. Jornada | 09.10.2022 | Olancho FC | - | Honduras Progreso | 2:1 | ||||
| 13. Jornada | 17.10.2022 | Olimpia | - | Olancho FC | 0:1 |  |
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| 14. Jornada | 20.10.2022 | Olancho FC | - | Real Sociedad | 7:0 | ||||
| 15. Jornada | 24.10.2022 | Motagua | - | Olancho FC | 1:3 | ||||
| 16. Jornada | 06.11.2022 | Olancho FC | - | Lobos UPNFM | 3:0 | ||||
| 17. Jornada | 13.11.2022 | Real España | - | Olancho FC | 4:3 | ||||
| 18. Jornada | 19.11.2022 | Marathón | - | Olancho FC | 4:0 |
Honduras