| 2. Jornada | 15.01.2022 | Cruz Azul [Sub 20] | - | FC Juárez [Sub 20] | 0:0 | ||||
| 3. Jornada | 22.01.2022 | CF Monterrey [Sub 20] | - | Cruz Azul [Sub 20] | 2:2 |  |
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| 5. Jornada | 12.02.2022 | Cruz Azul [Sub 20] | - | Club Necaxa [Sub 20] | 0:1 | ||||
| 11. Jornada | 19.03.2022 | CF Pachuca [Sub 20] | - | Cruz Azul [Sub 20] | 1:0 |  |
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| 13. Jornada | 08.04.2022 | Mazatlán FC [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 15. Jornada | 21.04.2022 | Gallos Blancos [Sub 20] | - | Cruz Azul [Sub 20] | 1:3 | |
México