| 1. Jornada | 03.03.2018 | Toronto FC | - | Columbus Crew | 0:2 |  |
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| 1. Jornada | 10.03.2018 | Columbus Crew | - | Impact de Montréal | 3:2 | ||||
| 1. Jornada | 17.03.2018 | Philadelphia Union | - | Columbus Crew | 0:0 | ||||
| 1. Jornada | 24.03.2018 | Columbus Crew | - | D.C. United | 3:1 | ||||
| 1. Jornada | 31.03.2018 | Columbus Crew | - | Vancouver Whitecaps | 1:2 | ||||
| 2. Jornada | 08.04.2018 | Chicago Fire | - | Columbus Crew | 1:0 | ||||
| 2. Jornada | 15.04.2018 | D.C. United | - | Columbus Crew | 1:0 | ||||
| 2. Jornada | 22.04.2018 | Columbus Crew | - | New England Revolution | 2:2 | ||||
| 3. Jornada | 05.05.2018 | Seattle Sounders | - | Columbus Crew | 0:0 | ||||
| 3. Jornada | 10.05.2018 | Columbus Crew | - | Philadelphia Union | 1:0 | ||||
| 3. Jornada | 13.05.2018 | Columbus Crew | - | Chicago Fire | 3:0 | ||||
| 3. Jornada | 20.05.2018 | New England Revolution | - | Columbus Crew | 0:1 | ||||
| 3. Jornada | 28.05.2018 | Sporting Kansas City | - | Columbus Crew | 0:0 | ||||
| 4. Jornada | 14.06.2018 | Columbus Crew | - | Atlanta United FC | 0:2 |
Panamá
Estados Unidos