| 6. Jornada | 10.07.2022 | Chicago Fire | - | Columbus Crew | 2:3 |  |
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| 6. Jornada | 14.07.2022 | D.C. United | - | Columbus Crew | 2:2 | |
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| 6. Jornada | 18.07.2022 | Columbus Crew | - | FC Cincinnati | 2:0 | |
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| 6. Jornada | 24.07.2022 | Columbus Crew | - | New England Revolution | 0:0 | ||||
| 7. Jornada | 04.08.2022 | Columbus Crew | - | CF Montréal | 1:2 | ||||
| 7. Jornada | 07.08.2022 | Columbus Crew | - | New York City FC | 3:2 | |
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| 7. Jornada | 14.08.2022 | Colorado Rapids | - | Columbus Crew | 1:1 | |
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| 7. Jornada | 22.08.2022 | Columbus Crew | - | Atlanta United FC | 2:2 | |
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| 7. Jornada | 28.08.2022 | FC Cincinnati | - | Columbus Crew | 2:2 | ||||
| 7. Jornada | 01.09.2022 | Columbus Crew | - | Inter Miami CF | 1:0 | ||||
| 8. Jornada | 03.09.2022 | Columbus Crew | - | Chicago Fire | 0:0 | ||||
| 8. Jornada | 10.09.2022 | CF Montréal | - | Columbus Crew | 2:2 | ||||
| 8. Jornada | 14.09.2022 | Inter Miami CF | - | Columbus Crew | 2:1 | |
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| 8. Jornada | 18.09.2022 | Columbus Crew | - | Portland Timbers | 1:1 | |
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| 9. Jornada | 06.10.2022 | Charlotte FC | - | Columbus Crew | 2:2 | |
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| 9. Jornada | 09.10.2022 | Orlando City | - | Columbus Crew | 2:1 |
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