| 1. Jornada | 24.07.2021 | MFK Ružomberok | - | FK Senica | 0:0 | ||||
| 4. Jornada | 13.08.2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 5. Jornada | 21.08.2021 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
| 6. Jornada | 28.08.2021 | MFK Ružomberok | - | MFK Zemplín Michalovce | 0:0 | ||||
| 7. Jornada | 10.09.2021 | Zlaté Moravce | - | MFK Ružomberok | 2:2 |  |
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| 8. Jornada | 18.09.2021 | MFK Ružomberok | - | FC DAC 1904 | 1:2 | ||||
| 9. Jornada | 25.09.2021 | MŠK Žilina | - | MFK Ružomberok | 0:2 | ||||
| 10. Jornada | 02.10.2021 | MFK Ružomberok | - | Tatran Liptovský Mikuláš | 4:1 | ||||
| 11. Jornada | 16.10.2021 | FK Pohronie | - | MFK Ružomberok | 2:2 | ||||
| 12. Jornada | 23.10.2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
| 13. Jornada | 30.10.2021 | MFK Ružomberok | - | ŠKF Sereď | 3:1 | ||||
| 14. Jornada | 07.11.2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 15. Jornada | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Jornada | 28.11.2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
| 17. Jornada | 04.12.2021 | MFK Zemplín Michalovce | - | MFK Ružomberok | 0:3 | ||||
| 18. Jornada | 11.12.2021 | MFK Ružomberok | - | Zlaté Moravce | 1:1 |
Eslovaquia