| 12. Jornada | 24.04.2022 | Sportivo Ameliano | - | Cerro Porteño | 0:1 | ||||
| 13. Jornada | 01.05.2022 | Cerro Porteño | - | Club Nacional | 1:0 |  |
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| 14. Jornada | 09.05.2022 | Guaraní | - | Cerro Porteño | 1:2 | |
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| 15. Jornada | 12.05.2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
| 16. Jornada | 15.05.2022 | Sol de América | - | Cerro Porteño | 2:1 | ||||
| 17. Jornada | 22.05.2022 | Club Olimpia | - | Cerro Porteño | 0:4 | ||||
| 20. Jornada | 22.06.2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 | |
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| 21. Jornada | 26.06.2022 | Libertad | - | Cerro Porteño | 1:0 | ||||
| 22. Jornada | 02.07.2022 | Cerro Porteño | - | Tacuary | 1:0 |
Paraguay