| 2. Jornada | 21.07.2022 | Tacuary | - | Cerro Porteño | 0:1 |  |
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| 3. Jornada | 25.07.2022 | Cerro Porteño | - | Sol de América | 2:0 | ||||
| 4. Jornada | 30.07.2022 | Sportivo Ameliano | - | Cerro Porteño | 0:2 | ||||
| 13. Jornada | 26.09.2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 18. Jornada | 23.10.2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 19. Jornada | 28.10.2022 | Cerro Porteño | - | General Caballero DJLM | 2:1 |
Paraguay