| 1. Jornada | 06.02.2022 | Real Santa Cruz | - | Universitario de Sucre | 0:1 | ||||
| 2. Jornada | 13.02.2022 | Real Santa Cruz | - | CD Guabirá | 2:2 | ||||
| 4. Jornada | 26.02.2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 5. Jornada | 06.03.2022 | Real Santa Cruz | - | Club Aurora | 2:2 |  |
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| 6. Jornada | 12.03.2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
| 7. Jornada | 02.04.2022 | Real Santa Cruz | - | Oriente Petrolero | 2:1 | ||||
| 9. Jornada | 16.04.2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 | ||||
| 10. Jornada | 22.04.2022 | CD Guabirá | - | Real Santa Cruz | 1:0 | ||||
| 11. Jornada | 24.04.2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 |
Argentina
