| 1. Jornada | 29.08.2021 | UD SS Reyes | - | Extremadura UD | 1:0 | ||||
| 2. Jornada | 04.09.2021 | Extremadura UD | - | SD Logroñés | 0:0 | ||||
| 3. Jornada | 12.09.2021 | Unionistas CF | - | Extremadura UD | 3:0 | ||||
| 4. Jornada | 17.09.2021 | Extremadura UD | - | Racing de Ferrol | 1:0 | ||||
| 5. Jornada | 26.09.2021 | Extremadura UD | - | Rayo Majadahonda | 3:2 |  |
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| 6. Jornada | 03.10.2021 | CF Talavera | - | Extremadura UD | 1:1 | |
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| 7. Jornada | 09.10.2021 | Extremadura UD | - | Valladolid B | 1:0 | ||||
| 8. Jornada | 16.10.2021 | CyD Leonesa | - | Extremadura UD | 2:1 | |
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| 9. Jornada | 22.10.2021 | Extremadura UD | - | CD Tudelano | 1:1 | ||||
| 15. Jornada | 04.12.2021 | Extremadura UD | - | Zamora CF | 2:2 | ||||
| 16. Jornada | 12.12.2021 | UD Logroñés | - | Extremadura UD | 1:3 | ||||
| 17. Jornada | 18.12.2021 | Extremadura UD | - | Real Racing | 2:4 |
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