| 2. Jornada | 22.02.2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 |  |
|||
| 3. Jornada | 02.03.2022 | Santiago Wanderers | - | Santiago Morning | 2:2 | ||||
| 4. Jornada | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 5. Jornada | 17.03.2022 | Santiago Wanderers | - | Rangers | 1:3 | ||||
| 6. Jornada | 22.03.2022 | Fernández Vial | - | Santiago Wanderers | 0:0 | ||||
| 7. Jornada | 03.04.2022 | Santiago Wanderers | - | CD Magallanes | 0:2 | |
|||
| 8. Jornada | 09.04.2022 | Deportes Copiapó | - | Santiago Wanderers | 1:1 | ||||
| 9. Jornada | 16.04.2022 | Santiago Wanderers | - | Puerto Montt | 2:0 | ||||
| 10. Jornada | 21.04.2022 | Deportes Melipilla | - | Santiago Wanderers | 2:0 |  |
|||
| 14. Jornada | 13.05.2022 | Cobreloa | - | Santiago Wanderers | 1:1 | ||||
| 15. Jornada | 17.05.2022 | Santiago Wanderers | - | Universidad de Concepción | 0:0 |
Chile