| 1. Jornada | 24.01.2016 | River Plate | - | Cerro Porteño | 0:2 | ||||
| 2. Jornada | 29.01.2016 | Sol de América | - | River Plate | 0:1 | ||||
| 3. Jornada | 04.02.2016 | River Plate | - | Sportivo Luqueño | 0:1 | ||||
| 4. Jornada | 09.02.2016 | Libertad | - | River Plate | 3:1 |  |
|||
| 7. Jornada | 27.02.2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Jornada | 02.03.2016 | Deportivo Capiatá | - | River Plate | 1:1 | ||||
| 9. Jornada | 05.03.2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
| 12. Jornada | 01.04.2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 13. Jornada | 06.04.2016 | River Plate | - | Sol de América | 1:1 | ||||
| 14. Jornada | 11.04.2016 | Sportivo Luqueño | - | River Plate | 2:0 |  |
|||
| 15. Jornada | 17.04.2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Jornada | 21.04.2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 18. Jornada | 01.05.2016 | Guaraní | - | River Plate | 4:2 | ||||
| 19. Jornada | 06.05.2016 | River Plate | - | Deportivo Capiatá | 1:1 | ||||
| 20. Jornada | 08.05.2016 | Club Rubio Ñu | - | River Plate | 1:2 | |
|||
| 21. Jornada | 14.05.2016 | River Plate | - | General Díaz | 1:1 | ||||
| 22. Jornada | 22.05.2016 | Club Olimpia | - | River Plate | 3:0 |
Paraguay