| 4. Jornada | 05.02.2022 | CF América [Sub 18] | - | Atlético San Luis [Sub 18] | 3:1 | ||||
| 8. Jornada | 01.03.2022 | CF América [Sub 18] | - | Gallos Blancos [Sub 18] | 1:0 |  |
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| 11. Jornada | 20.03.2022 | CF América [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:2 | ||||
| 14. Jornada | 15.04.2022 | Club Tijuana [Sub 18] | - | CF América [Sub 18] | 2:0 |
México