| 1. Jornada | 19.09.2021 | Mazatlán FC [] | - | Club León [] | 2:2 | ||||
| 2. Jornada | 25.09.2021 | CF Monterrey [] | - | Mazatlán FC [] | 4:1 |  |
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| 3. Jornada | 02.10.2021 | Mazatlán FC [] | - | UANL Tigres [] | 1:1 | ||||
| 4. Jornada | 09.10.2021 | Mazatlán FC [] | - | Santos Laguna [] | 0:2 | ||||
| 5. Jornada | 16.10.2021 | Club León [] | - | Mazatlán FC [] | 4:2 | ||||
| 6. Jornada | 23.10.2021 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 3:0 | ||||
| 7. Jornada | 30.10.2021 | Mazatlán FC [] | - | Atlas Guadalajara [] | 1:2 | ||||
| 8. Jornada | 06.11.2021 | Atlético San Luis [] | - | Mazatlán FC [] | 2:2 | ||||
| 9. Jornada | 13.11.2021 | Mazatlán FC [] | - | Club Necaxa [] | 1:3 |
México