| 1. Jornada | 24.07.2021 | Lokomotiv Moskva | - | Arsenal Tula | 3:1 | ||||
| 2. Jornada | 30.07.2021 | Arsenal Tula | - | Rubin Kazan | 0:3 | ||||
| 3. Jornada | 07.08.2021 | Arsenal Tula | - | Krylia Sovetov | 2:1 |  |
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| 4. Jornada | 15.08.2021 | FK Krasnodar | - | Arsenal Tula | 3:2 | ||||
| 5. Jornada | 21.08.2021 | Arsenal Tula | - | Spartak Moskva | 1:1 | |
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| 6. Jornada | 26.08.2021 | Akhmat Grozny | - | Arsenal Tula | 2:1 | ||||
| 7. Jornada | 12.09.2021 | Arsenal Tula | - | CSKA Moscú | 2:2 | ||||
| 8. Jornada | 19.09.2021 | FK Nizhny Novgorod | - | Arsenal Tula | 2:3 | ||||
| 9. Jornada | 27.09.2021 | FK Ural | - | Arsenal Tula | 2:0 | ||||
| 10. Jornada | 02.10.2021 | Arsenal Tula | - | FK Khimki | 0:0 | ||||
| 11. Jornada | 16.10.2021 | Arsenal Tula | - | Zenit | 2:1 | |
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| 12. Jornada | 23.10.2021 | FK Rostov | - | Arsenal Tula | 4:0 | ||||
| 13. Jornada | 31.10.2021 | Arsenal Tula | - | FK Sochi | 1:2 | ||||
| 14. Jornada | 06.11.2021 | Arsenal Tula | - | FK Ufa | 0:0 | ||||
| 15. Jornada | 21.11.2021 | Dinamo Moskva | - | Arsenal Tula | 5:1 | |
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| 16. Jornada | 29.11.2021 | Arsenal Tula | - | Lokomotiv Moskva | 3:1 | |
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Ucrania