| 1. Jornada | 21.08.2021 | Paphos FC | - | APOEL Nikosia | 4:0 | ||||
| 2. Jornada | 13.09.2021 | APOEL Nikosia | - | Olympiacos Nikosia | 0:1 | ||||
| 3. Jornada | 19.09.2021 | Apollon Limassol | - | APOEL Nikosia | 2:1 | ||||
| 4. Jornada | 27.09.2021 | APOEL Nikosia | - | PAEEK | 1:0 | ||||
| 5. Jornada | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 |  |
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| 6. Jornada | 18.10.2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 12. Jornada | 05.12.2021 | APOEL Nikosia | - | Paphos FC | 1:1 | ||||
| 13. Jornada | 12.12.2021 | Olympiacos Nikosia | - | APOEL Nikosia | 1:1 | ||||
| 14. Jornada | 18.12.2021 | APOEL Nikosia | - | Apollon Limassol | 1:1 | |
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| 19. Jornada | 30.01.2022 | APOEL Nikosia | - | Doxa Katokopias | 2:0 |
Brasil