| 1. Jornada | 27.03.2010 | Columbus Crew | - | Toronto FC | 2:0 | ||||
| 2. Jornada | 11.04.2010 | FC Dallas | - | Columbus Crew | 2:2 |  |
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| 3. Jornada | 02.05.2010 | Seattle Sounders | - | Columbus Crew | 1:1 |  |
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| 3. Jornada | 16.05.2010 | Columbus Crew | - | CD Chivas | 1:0 | ||||
| 3. Jornada | 21.05.2010 | New York RB | - | Columbus Crew | 1:3 | ||||
| 3. Jornada | 23.05.2010 | Kansas City Wizards | - | Columbus Crew | 0:1 | ||||
| 5. Jornada | 04.07.2010 | Columbus Crew | - | Chicago Fire | 2:1 | ||||
| 5. Jornada | 11.07.2010 | Houston Dynamo | - | Columbus Crew | 0:0 | ||||
| 5. Jornada | 18.07.2010 | Columbus Crew | - | New York RB | 2:0 | ||||
| 5. Jornada | 25.07.2010 | Columbus Crew | - | Houston Dynamo | 3:0 |  |
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| 6. Jornada | 01.08.2010 | CD Chivas | - | Columbus Crew | 3:1 | ||||
| 6. Jornada | 06.08.2010 | Philadelphia Union | - | Columbus Crew | 1:2 | ||||
| 6. Jornada | 15.08.2010 | Real Salt Lake | - | Columbus Crew | 2:0 | ||||
| 6. Jornada | 22.08.2010 | Columbus Crew | - | Colorado Rapids | 3:1 | ||||
| 6. Jornada | 28.08.2010 | Columbus Crew | - | FC Dallas | 0:0 | ||||
| 7. Jornada | 05.09.2010 | D.C. United | - | Columbus Crew | 0:1 | ||||
| 7. Jornada | 19.09.2010 | Columbus Crew | - | Seattle Sounders | 0:4 |
Estados Unidos