| 2. Jornada | 24.07.2022 | CS Herediano | - | Guadalupe | 1:0 |  |
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| 3. Jornada | 31.07.2022 | Santos de Guápiles | - | Guadalupe | 3:3 | ||||
| 5. Jornada | 11.08.2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 6. Jornada | 15.08.2022 | Guadalupe | - | AD Guanacasteca | 1:0 | ||||
| 7. Jornada | 22.08.2022 | Sporting FC | - | Guadalupe | 4:2 | ||||
| 8. Jornada | 28.08.2022 | Guadalupe | - | Santos de Guápiles | 3:0 | |
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| 9. Jornada | 01.09.2022 | LD Alajuelense | - | Guadalupe | 1:0 | ||||
| 10. Jornada | 04.09.2022 | Guadalupe | - | CS Herediano | 0:5 | ||||
| 11. Jornada | 11.09.2022 | Municipal Pérez Zeledón | - | Guadalupe | 2:1 | |
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| 12. Jornada | 18.09.2022 | CS Cartaginés | - | Guadalupe | 3:0 | ||||
| 13. Jornada | 22.09.2022 | Guadalupe | - | AD San Carlos | 2:1 | ||||
| 15. Jornada | 29.09.2022 | Puntarenas FC | - | Guadalupe | 0:2 | |
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| 16. Jornada | 03.10.2022 | Guadalupe | - | Deportivo Saprissa | 1:2 |
Costa Rica