| 2. Jornada | 15.01.2022 | UANL Tigres [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | ||||
| 4. Jornada | 06.02.2022 | UANL Tigres [Sub 20] | - | Mazatlán FC [Sub 20] | 3:2 | ||||
| 5. Jornada | 12.02.2022 | Deportivo Guadalajara [Sub 20] | - | UANL Tigres [Sub 20] | 0:1 | ||||
| 6. Jornada | 19.02.2022 | UANL Tigres [Sub 20] | - | Atlético San Luis [Sub 20] | 1:1 | ||||
| 10. Jornada | 12.03.2022 | Club León [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | ||||
| 11. Jornada | 19.03.2022 | UANL Tigres [Sub 20] | - | CF Monterrey [Sub 20] | 0:1 |
México