| 1. Jornada | 25.07.2021 | Dynamo České Budějovice | - | FK Teplice | 1:0 |  |
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| 2. Jornada | 30.07.2021 | FK Teplice | - | Slavia Praga | 1:3 |  |
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| 3. Jornada | 07.08.2021 | FC Fastav Zlín | - | FK Teplice | 3:0 | ||||
| 4. Jornada | 15.08.2021 | FK Teplice | - | FK Jablonec | 1:0 | ||||
| 5. Jornada | 21.08.2021 | FK Mladá Boleslav | - | FK Teplice | 3:1 | ||||
| 6. Jornada | 29.08.2021 | Bohemians Praha 1905 | - | FK Teplice | 4:2 | ||||
| 7. Jornada | 11.09.2021 | FK Teplice | - | Baník Ostrava | 1:2 | ||||
| 8. Jornada | 19.09.2021 | MFK Karviná | - | FK Teplice | 1:1 | |
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| 9. Jornada | 26.09.2021 | FK Teplice | - | Sigma Olomouc | 0:0 | ||||
| 10. Jornada | 02.10.2021 | 1. FC Slovácko | - | FK Teplice | 3:2 | ||||
| 11. Jornada | 17.10.2021 | FK Teplice | - | Viktoria Plzeň | 0:1 | |
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| 12. Jornada | 24.10.2021 | FC Hradec Králové | - | FK Teplice | 3:0 | ||||
| 15. Jornada | 21.11.2021 | FK Teplice | - | FK Pardubice | 1:2 | ||||
| 16. Jornada | 28.11.2021 | Slavia Praga | - | FK Teplice | 3:0 |
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