| 1. Jornada | 13.03.2022 | San Antonio FC | - | Detroit City FC | 1:0 | ||||
| 1. Jornada | 20.03.2022 | Los Angeles Galaxy II | - | San Antonio FC | 1:2 |  |
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| 1. Jornada | 28.03.2022 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | |
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| 2. Jornada | 03.04.2022 | San Antonio FC | - | Phoenix Rising | 0:2 | ||||
| 3. Jornada | 08.05.2022 | Phoenix Rising | - | San Antonio FC | 3:0 | ||||
| 3. Jornada | 29.05.2022 | Rio Grande Valley FC | - | San Antonio FC | 2:3 | ||||
| 4. Jornada | 05.06.2022 | Sacramento Republic | - | San Antonio FC | 1:0 | ||||
| 4. Jornada | 12.06.2022 | Monterey Bay FC | - | San Antonio FC | 2:3 | ||||
| 4. Jornada | 19.06.2022 | San Antonio FC | - | Oakland Roots | 1:1 | ||||
| 4. Jornada | 25.06.2022 | Colorado Springs Switchbacks | - | San Antonio FC | 0:1 | ||||
| 8. Jornada | 02.10.2022 | Pittsburgh Riverhounds | - | San Antonio FC | 0:1 | ||||
| 8. Jornada | 09.10.2022 | Birmingham Legion | - | San Antonio FC | 1:2 | ||||
| 8. Jornada | 16.10.2022 | San Antonio FC | - | Orange County SC | 2:2 |
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